Moreover, OXY can induce caspase-dependent cell apoptosis via ROS generation in the triple-negative breast cancer MDA-MB-231 cell line [28], induce cell apoptosis through STAT3 signaling blockage in osteosarcoma Saos-2 cells [29], show a selective cytotoxic effect on the BGC-823 cell line [30], downregulate gene expression and protein levels of vascular endothelial growth factor (VEGF), and inhibit cell growth and migration in a dose-dependent manner in HSC-3, HN-8, and HN-30 cell lines [31]. The gene discussed is VEGFA; the disease is osteosarcoma.