Recently, Rutaecarpine has been tested, among others, and it turned out that it improves neuronal damage, and inhibits apoptosis, inflammation, and oxidative stress by regulating the expression of the ERK1/2 and Nrf2/HO-1 pathway in rats with cerebral ischemia–reperfusion injury [280]. This evidence concerns the gene HMOX1 and Cerebral ischemia.