Pearson correlation analysis showed a moderate positive correlation between BMAL1 and SIRT1, as well as between BMAL1 and SOD (r = 0.69; r = 0.73, respectively), indicating that SIRT1-BMAL1 may contribute to the early onset of ischemic stroke by regulating oxidative stress [115]. The gene discussed is SOD1; the disease is ischemic stroke.