GRIN1 and schizophrenia: Considering that the NMDAR requires three events for activation, namely the depolarization of the plasma membrane, the binding of D-serine/glycine to the glycine modulatory site in GluN1, and the binding of L-glutamate to the glutamine binding site in GluN2 [40], the glycine modulatory site in GluN1 plays an important role in the pathophysiology of schizophrenia or cognition.