Both the mRNA and protein expressions of the GluN1 and GluN2C subunits in the prefrontal cortices of patients with schizophrenia were significantly decreased in comparison to that in healthy controls, whereas changes in the other subunits, such as GluN2A, GluN2B, GluN2D, and GluN3, in the prefrontal cortex were not observed [73,74]. The gene discussed is GRIN1; the disease is schizophrenia.