CXCL8 and neoplasm: CXCL8 is a cytokine that regulates the chemotaxis and activation of leukocytes, such as neutrophils and macrophages. It not only promotes tumor cell proliferation, invasion, and metastasis in tumor development and participates in tumor immune escape, but also causes plaque instability in atherosclerosis by attracting immune cells and promoting vascular cell migration. In liver pathology, CXCL8 drives inflammation and injury.