We examine the primary hypothesis that TRAIL, OPG, and IL-18 are associated with CAD, firstly comparing these levels in acute ST-elevation myocardial infarction (STEMI) versus no STEMI, and then in association with the burden of CAD, as identified by means of computed tomography coronary angiography (CTCA), the current gold-standard non-invasive technique to definitively identify patients with and without atherosclerosis. This evidence concerns the gene TNFRSF11B and coronary artery disorder.