Meanwhile, the present study investigated the active substances and pharmacodynamic mechanism associated with the sedative-hypnotic effect of CXEO-FCEO-CNF, which may inhibit the JAK-STAT pathway to suppress neuroinflammation and regulate oxidative stress, neurotransmitter levels, and stress hormone levels in the HPA axis to comprehensively regulate insomnia. This evidence concerns the gene SOAT1 and insomnia.