As shown in Supplementary Figure S5, the expression of angiogenic factors (e.g., Angiopoetinn-1, FGF acidic), chemokines (e.g., CCL2, CXCL13), and inflammatory cytokines (e.g., IL-6, IL-1 beta), which were elevated in serum from tumor embedded mice, was suppressed by Pn-21Ab administration. This evidence concerns the gene CCL2 and neoplasm.