Even eosinophil degranulation products, such as eosinophil-derived neurotoxin (EDN), eosinophil peroxidase (EPO), eosinophil cationic protein (ECP), or major basic protein (MBP), are possible contributors in EoE development, via DC activation and membrane permeability induction [69]. Here, RNASE2 is linked to eosinophilic esophagitis.