To investigate the ability of irradiation associated with PARP inhibition to alter DNA repair, whole cell lysates of OUMS27 and JJ012 chondrosarcoma cells were harvested 24 h following 4 Gy X-ray or 2 Gy C-ion irradiation and prepared for western blot analysis (Figure 5). This evidence concerns the gene PARP1 and chondrosarcoma.