In fibroblasts from patients affected by Ehlers-Danlos syndrome spondylodysplastic type 1 (formerly known as “EDS progeroid form”, MIM 130070), which is caused by galactosyltransferase I deficiency, an enzyme involved in the synthesis of the tetrasaccharide linker region, about 50% of decorin was secreted as a core protein in addition to its glycanated form [36,37]. Here, DCN is linked to Ehlers-Danlos syndrome, progeroid type.