AKT1 and Familial prostate cancer: Moreover, in PTEN-negative prostate cancer cells, plectin binds to actin-rich adhesions, leading to the activation of epidermal growth factor receptor (EGFR)/phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB) and focal adhesion kinase (FAK)/Src pathways [41,42,43].