This work aimed to investigate if the determination of GluAp, AlaAp, and/or DPP4 in urine collected at admission in the intensive care unit (ICU) could be useful in the early diagnosis of CSA-AKI, comparing their diagnostic sensitivity and specificity with AKIN criteria and other urinary markers such as proteinuria, albuminuria, NAG, and NGAL. The gene discussed is LCN2; the disease is acute kidney injury.