These pathways included long-term depression, chemical carcinogenesis DNA adducts, measles, the renin–angiotensin system, MAPK signalling pathway, ether lipid metabolism, etc. There were 315 downregulated pathways found, of which 22 were significant, including tuberculosis, phagosome, measles, etc. (Figure 7). The gene discussed is REN; the disease is measles.