In addition, the altered function of enzymes involved in the repair of oxidative DNA damage, e.g., 8-oxoguanine DNA N-glycosylase 1 (hOGG1) and mutY DNA glycosylase (MUTYH), results in the accumulation of DNA mutations and contributes to the adenoma-adenocarcinoma transition [184]. Here, MUTYH is linked to adenocarcinoma.