The top three WGP ingredients (quercetin, EGCG, and kaempferol) could bind stably to the top four core genes of aging, atherosclerosis, and fatigue (FOS, ESR1, MAPK8, and SP1), except that EGCG could not dock successfully with SP1 (Figure 13A–I and Figures S5–S7). The gene discussed is ESR1; the disease is atherosclerosis.