However, the T2DM + SFFE + brusatol treatment did not show any significant variations in the levels of any of these markers, as compared with T2DM rats, indicating that the SFFE hypoglycemic effect is independent of modulating insulin levels but most likely due to an Nrf2-dependent suppression of hepatic gluconeogenesis. Here, NFE2L2 is linked to type 2 diabetes mellitus.