However, overactivation or hepatocyte-specific activation of Nrf2 prevented hepatic steatosis and the progression of nonalcoholic steatohepatitis (NASH) in HFD rats by suppressing hepatocyte oxidative damage, inflammation, and lipid accumulation [17,29,30,31,32,33]. Here, NFE2L2 is linked to metabolic dysfunction-associated steatohepatitis.