TARDBP and frontotemporal dementia: In the FTD CaMKII-TDP-43 mouse model, overexpression of the TDP-43 protein in neurons of the prefrontal cortex (PFC) and hippocampus has been shown to replicate disease-specific changes, including cognitive impairments, pathological mislocalization of TDP-43, and increased gliosis [12,14,18].