Recently, our group reported that in a transgenic FTD model with TDP-43 protein overexpression in forebrain neurons (FTD-TDP-43), there was only a significantly decreased expression of the NRF2-dependent enzyme NQO1 in the prefrontal cortex (PFC) of these mice, which cannot be attributed to alterations in the NRF2 pathway [11]. The gene discussed is NQO1; the disease is frontotemporal dementia.