Protein misfolding is a common feature in many neurodegenerative diseases [17,30]: AD is marked by beta-amyloid (Aβ) plaques and tau tangles [3,31], PD is marked by alpha-synuclein aggregates forming Lewy bodies [32], Huntington’s disease (HD) is marked by mutant huntingtin protein [33], and Amyotrophic lateral sclerosis (ALS) is marked by various protein aggregates like TAR DNA-binding protein 43 (TDP-43) and superoxide dismutase 1 (SOD1) [34]. Here, MAPT is linked to amyotrophic lateral sclerosis.