TP53 and cervical cancer: In OV2008 (chemosensitive) and C13 (chemoresistant) human cervical cancer cell lines, crocin induces apoptosis by up-regulating the expression of proapoptotic factors Bax and p53, while down-regulating the expression of the antiapoptotic factor Bcl-2 and its upstream regulator, miR-365 [163].