PARP1 and malignant colon neoplasm: Regarding colon cancer, lycopene induces apoptosis in HT-29 cell line due to a decrease in the expression levels of procaspases-8, -3 and -9, as well as PARP-1 and B-cell lymphoma 2 protein (Bcl-2), accompanied by an enhancement in Bcl-2-associated X-protein (Bax) expression [81,122].