On the other hand, it has been demonstrated that delphinidin, potent anthocyanidins in berries, inhibited the TPA-induced neoplastic cell transformation of mouse epidermal JB6 P+ cells by inducing the activation of Nrf2 and its target genes involved in phase II antioxidant cell response (i.e., HO-1), suggesting delphinidin as a potential skin cancer chemopreventive molecule thanks to its ability to activate Nrf2-ARE pathway [152]. This evidence concerns the gene NFE2L2 and skin cancer.