Regarding the genetic factors related to melanoma, the polymorphisms of the melanocortin 1 receptor (MC1R) gene are associated with cancer development [102] MC1R is a G protein-coupled receptor characterized by seven transmembrane segments, an extracellular N-terminus, and an intracellular C-terminus located on the cell surface of melanocytes [103]. The gene discussed is MC1R; the disease is melanoma.