NFKB1 and cancer: In addition, in a different study, it was observed that CR6-interacting factor 1 (Crif1), a novel factor involved in the assembly of oxidative phosphorylation (OXPHOS) complexes in mitochondria, promotes the hepatocellular carcinoma growth by the redox activation of NF-κB pathway [40], confirming, therefore, the role of NF-κB in cancer progression.