In addition, Yu and colleagues confirmed the pro-tumorigenic role of Nrf2, showing how tetrahydroisoquinoline alkaloids, renieramycin T inhibit B16F10 mouse melanoma cells migration and invasion, probably through the phosphorylation of the Signal Transducer and Activator of Transcription 3 (STAT3) and the downregulation of Nrf2, suggesting their crosstalk in melanoma progression [151]. The gene discussed is NFE2L2; the disease is melanoma.