BRAF and melanoma: Regarding somatic mutations, melanomas are divided into four subtypes: (1) B-Raf proto-oncogene serine/threonine kinase mutant (BRAF), (2) NRAS proto-oncogene GTPase mutant (NRAS), (3) neurofibromin 1 mutant (NF1), and (4) triple wild-type (WT) BRAF/NRAS/NF1 [95].