In melanoma cells, Hyperforin downregulates several cytosolic (phosphoglucomutase 2 (PGM2), lactate dehydrogenase A (LDHA), and the phosphorylated form of pyruvate kinase M2 (pPKM2)) and mitochondrial (ubiquinol cytochrome c reductase (UQCRC1), cytochrome c oxidase subunit IV (COX4), and ATP synthase F1 subunit β (ATP5B)) enzymes, indicating a generalized decrease of metabolic functions. Here, PGM2 is linked to melanoma.