A significant 1.8-fold (p < 0.05), 2.0-fold (p < 0.01), and 2.4-fold (p < 0.001) higher granulation tissue formation was noticed in the apoA-I:CIGB258 at 1:0.1, 1:0.5, and 1:1 treated wound as compared to the only CML exposed wound signifying the potency of CIGB-258 towards CML impaired wound healing. This evidence concerns the gene APOA1 and chronic myelogenous leukemia, BCR-ABL1 positive.