High-density lipoproteins (HDL) and apolipoprotein A-I (apoA-I) are well recognized for their antioxidant, anti-glycation, and anti-inflammatory properties in the bloodstream, which help to mitigate the risk of type 2 diabetes, rheumatoid arthritis, and sepsis [1,2,3]. The gene discussed is APOA1; the disease is Sepsis.