At a 1:1 molar concentration of apoA-I and CIGB-258, the HDL-C level was detected to be substantially 2-fold and 3-fold higher compared to the HDL-C levels observed in apoA-I alone (1:0 molar ratio) and CML-injected groups, respectively, testifying to the efficacy of CIGB-258 in elevating plasma HDL-C level. The gene discussed is APOA1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.