A significant 2.3-fold (p < 0.01), 2.6-fold (p < 0.001), and 4.5-fold (p < 0.001) reduced AO fluorescent intensity corresponding to the apoptosis was noticed in apoA-I:CIGB-258 at 1:0.1, 1:0.5 and 1:1 treated wound, respectively, than the wound exposed to the CML only. This evidence concerns the gene APOA1 and chronic myelogenous leukemia, BCR-ABL1 positive.