APOA1 and chronic myelogenous leukemia, BCR-ABL1 positive: Interestingly, the neutrophil numbers were reduced gradually by the co-addition of apoA-I:CIGB-258 in a dose-dependent manner of CIGB-258 as evidenced by 13%, 60% (p < 0.05), 71% (p < 0.05), and 88% (p < 0.01) reduced neutrophil counts, respectively, than that of CML+PBS group.