In the mucosa of GERD patients, high levels of inflammatory cytokines have been detected, such as interleukin-8 (IL-8), which is one of the most important neutrophil chemoattractants, IL-1β, tumor necrosis factor-α (TNF-α), and platelet activating factor (PAF), which contribute to GERD pathogenesis [13]. This evidence concerns the gene PCLAF and gastroesophageal reflux disease.