OCLN and gastroesophageal reflux disease: Our results demonstrated a decrease of the claudin-1, ZO-1, filaggrin, and occludin levels in the GERD + vehicle group compared to the Sham + vehicle group (Figure 5A–D); however, following bombesin treatment at the highest doses of 0.5 mg/kg and 1 mg/kg, we observed a considerable re-establishment of the TJ levels (Figure 5A–D).