Notably, it has been shown by us and other research groups that Nrf2 signaling plays an important role in resistance to radiation [11,14]; therefore, targeting Nrf2 signaling is potentially a way to overcome radioresistance in some tumors with poor prognoses, such as glioblastoma and pancreatic cancers [7,15]. The gene discussed is NFE2L2; the disease is familial pancreatic carcinoma.