STAT3 and colorectal carcinoma: To elucidate whether ALMS1‐IT1 modulates CRC immune response via STAT3, we generated ALMS1‐IT1 overexpression cell models by introducing ALMS1‐IT1 plasmids into Caco2 and HT29 cells, transfection effciencies were verified by qRT‐PCR and western blot (Figure 5A,B).