ACTA1 and cancer: This revealed that αSMA + FAP + mr-CAFs correlated with poor prognosis in multiple cancer types, including BLCA (P = 0.03), KIRC (P = 0), PAAD (P = 0.002), LUAD (P = 0.022), LUSC (P = 0.045) and a poor tendency in ESCA (P = 0.123) (Fig.S5E).