It was also found that there were differences between patients with HAE nC1-INH and those with AE-UNK; with stress and estrogen therapy less likely to be a trigger for patients with AE-UNK (65% vs. 26%, p = 0.007, and 35% vs. 9%, p = 0.031 respectively, Table 2). The gene discussed is COL18A1; the disease is hereditary angioedema.