SGPL1 and nephrotic syndrome 14: Toward that end, we performed a retrospective analysis of 76 SPLIS patients in whom the diagnosis of SPLIS was established in a proband with at least one suggestive finding and biallelic SGPL1 variants identified by molecular genetic testing and for whom sufficient data were available for analysis, e.g., genotype, number of cases reported per year, country of origin, follow up of at least 6 months for living patients.