AURKA physiologically interacts with LKB1 and phosphorylates it at S299, which impairs the association of LKB1 with its main substrate, AMPK, which in turn inhibits LKB1’s tumor-suppressive roles, thereby facilitating NSCLC growth and migration (Fig. 7C) (Table 1). Here, STK11 is linked to non-small cell lung carcinoma.