In glioma TME, the cytokines IFN-γ and IL-6 can act on immune cells such as glioma cells and phagocytes to increase the expression of PD-L1, and finally bind to PD-1 on TIL to inhibit the activation and proliferation of T cells, helping to maintain immune tolerance and prevent the occurrence of autoimmune reactions. Here, CD274 is linked to central nervous system cancer.