The classical VAGs (epf, mrp, and sly) are factors with proven or potential roles in the pathogenesis of the S. suis infection: EF, encoded by epf, has been postulated to enhance the bacterial survival in host tissues, MRP has been associated to immune evasion, and suilysin shown to contribute to septicemia and meningitis by lysing host cells [34, 35]. This evidence concerns the gene HSPE1 and meningitis.