Both CD4 + T and CD8 + T cells were widely distributed within the tumor bed and along its margins (Fig. 5, oHSV-1 treated; CD4,CD8, insets ×400), whereas they were less abundant and dispersed throughout the GL261 tumor mass in non-treated mice (Fig. 5, vehicle; CD4, CD8, insets ×400). Here, CD4 is linked to neoplasm.