NES and neoplasm: Interestingly, in oHSV-1-treated mice, a dense population of Nestin-positive peritumoral astrocytes was observed along the tumor bed, both in oHSV-1-treated and GL261-challenged tumors (Fig. 3B, oHSV-1, Fig. 4, oHSV-1 treated; Nestin, arrowheads).