On day 7 after infection, the lungs of IL-6−/− + rIL-6 mice (1.44 × 106 CFU/g) had significantly higher fungal burden than Wild-type (4.09 × 105 CFU/g; P < 0.01) and IL-6−/− (3.92 × 105 CFU/g; P < 0.01) mice, respectively (Fig. 2E). Here, IL6 is linked to infection.