Consistent with our observations for AMPK expression, knockdown of TRPV2 in breast cancer cells resulted in inhibition of ULK1 phosphorylation at serine 555 (Fig. 6A-C), while cannabidiol treatment led to upregulation of ULK1 phosphorylation (Fig. 6D-E). The gene discussed is ULK1; the disease is breast carcinoma.