AKT1 and small cell lung carcinoma: Among these pathways, dif-mRNAs for the ECM were enriched mainly in ECM-receptor interaction, focal adhesion, human papillomavirus infection, the PI3K-Akt signalling pathway, amoebic disease, small cell lung cancer, actin cytoskeleton regulation, hypertrophic cardiomyopathy, and arrhythmic right ventricular cardiomyopathy and cancer (Figure 9B and Additional file 11).