To further certify the involvement of PYK2 in fibrotic cataracts, we knocked down the PYK2 by siRNA and found that the knockdown of PYK2 can allay the TGFβ2-induced EMT by suppressing the phosphorylation of ERK, JNK, P38, and AKT. This evidence concerns the gene TGFB2 and cataract.