In addition, P Chaudhary et al. reported that ANXA2 interacts with epidermal growth factor receptor (EGFR) on the cell surface and plays a crucial role in malignant phenotypes (such as cancer cell proliferation and migration) by modulating the activation of the Raf-MEK-ERK and PI3K-AKT pathways [37]. The gene discussed is ANXA2; the disease is cancer.