CircSPECC1 encodes a new protein known as SPECC1-415aa, which can competitively bind to ANXA2, thus blocking the binding of ANXA2 to EGFR and inhibiting the phosphorylation of EGFR and AKT and thereby restoring the sensitivity of TMZ-resistant GBM cells to TMZ. The gene discussed is AKT1; the disease is glioblastoma.