Compared with the overexpression of wild-type ADAMTS1, overexpression of proteolytic inactive ADAMTS1 led to reductions in the secretion of cleaved VCAN (Fig. 5F), EGFR activation (Fig. 5G), invasive ability (Fig. 5H), and anoikis resistance (Fig. 5I) in RCC cell lines. The gene discussed is EGFR; the disease is renal cell carcinoma.