PFT-α treatment significantly downregulated p53 expression and reversed ADAMTS1 overexpression-induced increases in total EGFR and p-EGFR in Caki-1 and 786-O cells, suggesting that p53 is involved in ADAMTS1-modulated EGFR expression in RCC cells (Fig. 7E). The gene discussed is EGFR; the disease is renal cell carcinoma.