Moreover, EGFR-KD also reversed upregulation of ADAMTS1 in ADAMTS1-overexpressing Caki-1 and 786-O cells (Fig. 3E, Additional file 1: Supplementary Fig. 2E), suggesting that the EGFR might exert feedback regulation on ADAMTS1 expression in RCC cells. The gene discussed is EGFR; the disease is renal cell carcinoma.