RELA and diabetes mellitus: Noteworthy, Set7-dependent H3K4 mono-methylation of the NF-kB p65 subunit not only provides a mechanism for epigenetic memory in macrophages but, once transferred to myeloid progeny, also contributes to diabetes-induced trained immunity by increasing the generation of more inflammatory and senescent monocyte subsets from haematopoietic stem cells (HSCs) (Ostuni et al. 2013; Vinci et al. 2024).