SIRT1 deacetylates H3 histones at the human endothelial p66Shc promoter suppressing ROS production and promoting transcription of SOD, therefore SIRT1 activation could prevent hyperglycemia-induced endothelial dysfunction and avoids hyperglycemic memory (Paneni et al. 2013a, b, c; Zhou et al. 2011). This evidence concerns the gene SIRT1 and endothelial dysfunction.