AKT1S1 and cystic kidney disease: Compared with Akt1s1+/+Tsc2f/f; Cre mice, Akt1s1−/−Tsc2f/f; Cre mice exhibited smaller kidneys, lower ratios of kidney weight to body weight, fewer and smaller renal cysts, and lower cyst index (Fig. 2C–F, Supplementary Fig. 2).