Furthermore, it has been observed that the signaling of TGF-β1 is intricately associated with the hypoxic microenvironment, leading to the induction of tumor epithelial-mesenchymal transition (EMT) and fibrosis in a manner dependent on TGF-β1 (Mallikarjuna et al. 2022). The gene discussed is TGFB1; the disease is neoplasm.