Given previous human genetic studies show that the TrkC gene NTRK3 and the PTPσ gene PTPRS are associated with neuropsychiatric disorders such as panic disorder, OCD, schizophrenia, and ASDs (Alonso et al, 2008; Armengol et al, 2002; Gratacos et al, 2001; Muinos-Gimeno et al, 2009; Otnaess et al, 2009; Takahashi and Craig, 2013; Um and Ko, 2013; Verma et al, 2008), our results suggest that loss of TrkC–PTPσ interaction in vivo may result in neurodevelopmental disorder- and/or neuropsychiatric disorder-like behaviors. This evidence concerns the gene PTPRS and neurodevelopmental disorder.