NTRK3 and depressive symptom measurement: Given several previous human genetic studies showing linkage of NTRK3 with anxiety-related disorders including panic disorder and OCD, and mood disorders including major depression (Alonso et al, 2008; Armengol et al, 2002; Gratacos et al, 2001; Muinos-Gimeno et al, 2009; Takahashi and Craig, 2013; Um and Ko, 2013; Verma et al, 2008), we further performed behavioral experiments to assess anxiety, avoidance and depression behaviors in TrkC KI mice.