In line with published findings that NOD2−/− and RIPK2−/− mice are more susceptible to DSS-induced colitis than control mice (Couturier-Maillard et al, 2013), we found that Yod1−/− mice, accompanied with reduced RIPK2 levels, also developed more severe experimental colitis than did control mice. The gene discussed is YOD1; the disease is colitis.