NFKB1 and colitis: The DUB A20 serves as an important post-translational brake on the NF-κB signaling, and specific deletion of A20 in macrophages, intestinal epithelial cells (IECs), or dendritic cells predisposes mice to colitis (Hammer et al, 2011; Pu et al, 2021; Vereecke et al, 2010; Vereecke et al, 2014).