RND3 and glioblastoma: RND3 knockout mice develop hydrocephalus due to hyperplasia of the ependymal cells, this is due to augmented Notch signaling (NICD), mechanistically RND3 binds and promotes degradation of NICD through the UPS (Ubiquitin Proteasome System)47, augmented expression of RND3 in glioblastoma cell line decreases migration and invasion, conversely down regulation promotes increased migration, invasion and proliferation (U251) cells48, this is done at least partially by direct interaction of RND3 with Snail, promoting Snail degradation by the ubiquitin-proteasome degradation pathway.