In contrast, incoming signaling patterns in MAN1C1-expressing glioma cells stimulated the PTN, SPP1, MK, EGF, EDN, LIFR, OSM, IL6, ANGPLT, IGF, BPM, ncWNT, PARs, IL1, PERIOSTIN, NT, TWEAK, HGF, EPO, GDNF, IL17, FASLG, and FLT3 signaling pathways (Fig. 8F). Here, RNASE2 is linked to glioma.