In contrast, incoming signaling patterns in MAN1C1-expressing glioma cells stimulated the PTN, SPP1, MK, EGF, EDN, LIFR, OSM, IL6, ANGPLT, IGF, BPM, ncWNT, PARs, IL1, PERIOSTIN, NT, TWEAK, HGF, EPO, GDNF, IL17, FASLG, and FLT3 signaling pathways (Fig. 8F). This evidence concerns the gene GDNF and central nervous system cancer.