The outgoing signaling pattern in MAN1C1-expressing glioma cells showed that PTN, MK, MIF, VISFATIN, LIF, LIFR, ANNEXIN, OSM, IL6, PDGF, BMP, PROS, LT, NT, HGF, ACTIVIN, AGT, GDNF, FASNG, and FLT3 signaling pathways were significantly activated. This evidence concerns the gene GDNF and central nervous system cancer.