In contrast, incoming signaling patterns in MAN1C1-expressing glioma cells stimulated the PTN, SPP1, MK, EGF, EDN, LIFR, OSM, IL6, ANGPLT, IGF, BPM, ncWNT, PARs, IL1, PERIOSTIN, NT, TWEAK, HGF, EPO, GDNF, IL17, FASLG, and FLT3 signaling pathways (Fig. 8F). Here, TNFSF12 is linked to central nervous system cancer.