In contrast, incoming signaling patterns in MAN1C1-expressing glioma cells stimulated the PTN, SPP1, MK, EGF, EDN, LIFR, OSM, IL6, ANGPLT, IGF, BPM, ncWNT, PARs, IL1, PERIOSTIN, NT, TWEAK, HGF, EPO, GDNF, IL17, FASLG, and FLT3 signaling pathways (Fig. 8F). The gene discussed is SPP1; the disease is glioma.