Notably, SQSTM1/p62 was co-immunoprecipitated by both N999Vfs*40 and C975Vfs*73 KIF5A (Supplementary Fig. 8A), but was found exclusively at the rim of NEIMY-KIF5A aggregates, while it was clearly observed within ALS-KIF5A ones (Supplementary Fig. 8B). Here, KIF5A is linked to amyotrophic lateral sclerosis.