Conversely, both the CMT-linked R864* and the ALS-associated N999Vfs*40 KIF5A mutants preferentially localised within neurites, but with a distinct distribution pattern: the R864* mutant appeared diffused in neurites, while N999Vfs*40 KIF5A formed inclusions at neurite tips (Fig. 3A and quantification in Supplementary Fig. 3B). The gene discussed is KIF5A; the disease is amyotrophic lateral sclerosis.