Heterozygous missense variants in the motor and stalk domains are associated with spastic paraplegia type 10 (SPG10, Mendelian Inheritance in Man (MIM) #604187), a form of hereditary spastic paraplegia (HSP) [9], and axonal Charcot-Marie-Tooth disease (CMT) [10]. The gene discussed is KIF5A; the disease is hereditary spastic paraplegia.