Small peptides arising from non-canonical ORFs, such as CIP2A-BP, SRSP, and miPEP133 [48, 50, 53], serve not only as potential prognostic markers for specific cancer types but also as a significant source of neoantigens, distinct proteins/peptides exclusive to cancer cells and absent in normal tissues (Fig. 2E). This evidence concerns the gene LINC00665 and cancer.