TF and cancer: TransFac predicted activation of transcription factors (TFs) highlighted inflammatory TFs, including those belonging to the NF-κB pathway (NFKB1, RELA, NFKBIA), HDAC1, which converts fibroblast into cancer-associated fibroblasts (CAFs)46, RUNX1 which prognosticates immune infiltrate in CAFs47, as well as NEF2L2 which encodes the key antioxidant TF Nrf2, also known to promote metastasis in CAFs48 (Fig. 1N).