Given TRPV4’s abundant expression in endothelial and microglial cells, crucial components in the neuroinflammation process, TRPV4 inhibition offers multiple checkpoints to control stroke-induced neuroinflammation, targeting TRPV4 emerges as a promising therapeutic avenue to safeguard the BBB and modulate neuroinflammation, with implications for innovative strategies in managing these complex neurological conditions. Here, TRPV4 is linked to stroke disorder.