In Table 1 type of OI, appearance and form are specified.Most cases (> 80%) have autosomal-dominant heterozygote Mutation in Genes of collagensythesis (COL1A1 or COL1A2) [3]. In Germany an approximate of 4000 people are affected by OI [4]. The gene discussed is COL1A2; the disease is osteogenesis imperfecta.