Initially, this appearance is supported by the inverse correlation of ITLN1 expression, and genes related to the inflammatory response in VAT (e.g. CXCL8, TNF, NLRP3; see Table 2; see methods for unabbreviated gene names) Furthermore, the ITLN1 expression increase among people with obesity in our work appears to plateau earlier among IR persons (Fig. 2a), then among IS persons. The gene discussed is CXCL8; the disease is obesity disorder.