Initially, this appearance is supported by the inverse correlation of ITLN1 expression, and genes related to the inflammatory response in VAT (e.g. CXCL8, TNF, NLRP3; see Table 2; see methods for unabbreviated gene names) Furthermore, the ITLN1 expression increase among people with obesity in our work appears to plateau earlier among IR persons (Fig. 2a), then among IS persons. This evidence concerns the gene CXCL8 and obesity due to melanocortin 4 receptor deficiency.